| Type: | Pharmaceutical Intermediates, D-Mannitol |
|---|---|
| Appearance: | Powder, Powder |
| Quality: | Technical, Technical |
| Colour: | White, White |
| CAS No.: | D-Mannitol |
| Formula: | D-Mannitol |
| Samples: |
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| Customization: |
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Function
| Other Name | D-Mannitol |
| Assay | 99% |
| Apprearance | White crystalline powder |
| CAS | 69-65-8 |
| MF | C6H14O6 |
| Storage | Sealed in dark and dry place |
| Shelf Life | 2 Years |
D-Mannitol also known as Mannitol, It is a colorless to white acicular or rhombic columnar crystal or crystalline powder. It is odorless and has a cool sweet taste. The sweetness is 57% ~ 72% of that of sucrose. Each g produces 8.37 joules of heat, about half as much as glucose. Contains a small amount of sorbitol. Relative density 1.49. Optical rotation [α]D20-0.40°(10% aqueous). Hygroscopicity is minimal. Water soluble Chemicalbook solution is stable. Stable to dilute acid and alkali. It's not oxidized by oxygen in the air. Soluble in water (5.6g/100ml, 20ºC) and glycerin (5.5g/100m1). Slightly soluble in ethanol (1.2g/100m1). Soluble in hot ethanol. Almost insoluble in most other common organic solvents. The pH value of 20% aqueous solution is 5.5 ~ 6.5.
1. Food
Mannitol is one of the commonly used sugar alcohol substitutes and is often used in sugar-free chewing gum ingredients. Mannitol is the sugar alcohol with the least water absorption and can be used as food anti-sticking powder. my country's food additives use health standard GB 2760-2007 stipulates that it can be used for sugar-free chewing gum with a maximum amount of 200g/kg. JECFA confirmed that the ADI value is 0-50mg/(kg body weight·d). The US FDA stipulates that the maximum use of mannitol in various foods is as follows: mint 98%, soft candy 40%, hard candy 5%, candied fruit and ice cream 8%, cough drops 5%, jam and jelly 15%, gum candy 31%, other food 2.5%. Mannitol is listed in the United States Pharmacopoeia, Natural Medicines, and in the pharmacopoeias of countries around the world, including the Food Chemistry Handbook (FEC).
2. Medicine
Used as a large infusion of injection, used to lower cerebral pressure, intraocular pressure, and eliminate cerebral edema; used as a diuretic; kidney function and intestinal examination; oliguria and renal failure caused by edema and burns, mannitol infusion has a certain effect; and amino acids System compound infusion.
Because of its good compressibility, it has become an excellent excipient in the pharmaceutical industry.
In addition, mannitol mustard and mannitol bismethanesulfonic acid synthesized from mannitol are anti-tumor drugs, which are suitable for chronic leukemia.
3. Chemical
Mannitol is esterified and etherified to generate various resins and surfactants. Mannitol ester can be used as polyvinyl chloride plasticizer; and polyurethane rigid foam based on polyether produced by polymerization of oxide can be used as heat insulation, sound insulation, and moisture-proof materials.
Mannitol is one of the eight sugar alcohols.
It is a low-calorie food sweetener that contains 1.6 calories per gram compared to four calories per gram for sugar. It has about half the sweetness of sugar. Its glycemic index (GI) is a scant two compared to sugar's GI of 65.
Sugar alcohols like mannitol are excellent options for sweetening food without significantly elevating blood sugar.
Mannitol also doesn't contribute to tooth decay like sugar does.
|
Test Item |
Standard |
Result |
|
Appearance |
White crystalline powder |
White crystalline powder |
|
Assay(on dry basis) |
97-102 |
99.61 |
|
Water,% |
≤0.5 |
0.08 |
|
Melting Point,ºC |
165-170 |
167.5 |
|
Nickel,ppm |
≤1 |
<1 |
|
Heavy Meltal,ppm |
≤5 |
<5 |
|
Specific Rotation |
+23-+25 |
+24.3 |
|
Electrical conductivity,Hs/cm |
≤20 |
3.66 |
|
Reducing Sugars,% |
≤0.1 |
<0.1 |
|
Endotoxins,EU/g |
≤2.5 |
<2.5 |
|
The total no. of aerobe,cfu/g |
≤100 |
<10 |
|
Fungi cfu/g |
≤100 |
<10 |
|
Escherichia coli |
25g Negative |
Negative |
|
Salmonella |
25g Negative |
Negative |
|
Sorbitol,% |
≤2.0 |
<2 |
|
Isomalt,% |
≤2.0 |
<2 |
|
Malt,% |
≤2.0 |
<2 |
|
Conclusion: The above product conforms to the standard. |
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