Type: | Pharmaceutical Intermediates |
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Appearance: | Powder |
Quality: | Technical |
Colour: | White |
Certificate: | ISO SGS |
Purity: | 99% |
Customization: |
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Product Name: Dexmedetomidine hydrochloride
Synonyms: 4-[(1r)-1-(2,3-dimethylphenyl)ethyl]-3h-imidazole hydrochloride;4-((s)-alpha,2,3-trimethylbenzyl)imidazole monohydrochloride;DEXMEDETOMIDINE HCL;DEXMEDETOMIDINE HYDROCHLORIDE;DEMEDETOMIDINE HCL;Dexmedetomidine(Pilot);4-[(1S)-1-(2,3-Dimethylphenyl)ethyl]-1H-imidazolehydrochloride;4-((S)-α,2,3-Trimethylbenzyl)imidazole monohydrochloride
CAS: 145108-58-3
MF: C13H17ClN2
MW: 236.74
EINECS: 682-047-2
Product Categories: Inhibitors;API;145108-58-3
Mol File: 145108-58-3.mol
Dexmedetomidine was launched in the US as an i.v. infusion for sedation of initially intubated and mechanically ventilated patients during treatment in an intensive care unit, This imidazole derivative is the (S)-enantiomer of medetomidine that can be obtained via fractional crystallization of the tartrate salt of the racemic mixture. Dexmedetomidine is a full agonist of α2 adrenoceptors with 1300-fold selectivity versus α1 compared to the less selective partial α2 agonist clonidine, a veterinary hypnotic. Dexmedetomidine is unique compared with currently available sedatives in that it provides sedation, analgesia and anxiolysis with the ability of patients to be easily awakened. Besides, it causes minimal respiratory depression unlike other available drugs such as benzodiazepin e s or opioids. Pharmacological studies in transgenic mice showed that the sedative, anesthetic and analgesic effects of dexmedetomidine are specifically due to the stimulation of the a2A subtype receptor. Like other α2 adrenoceptor agonists, dexmedetomidine can provoke hypotension and bradycardia probably because of its non-selective action on peripheral a2B subtype receptors in vascular smooth muscle. Dexmedetomidine is extensively metabolized into methyl and glucuronide conjugates which are mainly eliminated by renal excretion. It was found to be a CYP2D6 inhibitor but less potent than the clinically relevant standard quinidine.
Dexmedetomidine Hcl CAS 145108-58-3 of Chemical Properties
Melting point 156.5-157.5°
alpha +52.4° (c = 1 in water)
density 1.17 g/cm3
storage temp. 2-8°C
solubility H2O: soluble20mg/mL, clear
form powder
color white to beige
optical activity [α]/D +48 to +58°, c = 1 in H2O
Merck 14,2946
InChIKey VPNGEIHDPSLNMU-MERQFXBCSA-N
CAS DataBase Reference 145108-58-3(CAS DataBase Reference)
Function and Application of Dexmedetomidine Hcl CAS 145108-58-3
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