Factoryhot Sale API Powder 99% Finasteride Dutasteride Ru58841 Minoxidil Powder

• CAS No.: Finasteride Dutasteride Ru58841 Minoxidil Powder
• Formula: Finasteride Dutasteride Ru58841 Minoxidil Powder
• EINECS: Finasteride Dutasteride Ru58841 Minoxidil Powder
• Type: Finasteride Dutasteride Ru58841 Minoxidil Powder, Pharmaceutical Intermediates
• Appearance: Powder
• Quality: Industrial, Technical
• Model NO.: Finasteride
• Colour: White
• Safe Customs Clearance: 100%
• Factory Price: Competitive
• Visit The Factory: Welcome
• Purity: 99%
• Delivery Time: 3 Days
• Transport Package: Bag
• Specification: bag
• Origin: China
• Production Capacity: 5000 Mt/Year

Product Description

Product Description

  

 

 China Factory Supply Dutasteride Pharmaceutical Chemical

 

PRODUCT NAME	Dutasteride CAS 164656-23-9
CAS NO.	Dutasteride CAS 164656-23-9
PURITY	99%
MELTING POINT	242-250°C
BOILING POINT	620.3±55.0 °C
DENSITY	1.303±0.06 g/cm3
SOLUBILITY	DMSO: soluble2mg/mL, clear
APPERANCE	White Powder
APPLICATION	Organic intermediates, biochemical reagents
CHEMICAL STRUCTURE
USAGE	Similar to finasteride, dutasteride is a competitive and mechanism-based inhibitor not only of type 2 but also of type 1 5α-reductase isoenzymes, with which stable enzyme-NADP adduct complexes are formed, inhibiting the conversion to DHT. The suppression of both type 1 and type 2 isoforms results in greater and more consistent reduction of plasma DHT than that observed for finasteride. The more effective dual inhibition of type 1 and type 2 5α-reductase isoforms lowers circulating DHT to a greater extent than with finasteride and shows advantages in treating BPH and other disease states (e.g., prostate cancer) that are DHT-dependent.
SOTRAGE	Sealed containers at cool & dry place. Protect from sunlight, moisture and pest infestation.

Product Name: Dutasteride
CAS No.:  164656-23-9
Molecular Formula: C27H30F6N2O2
Molecular Weight: 528.53g/mol
Purity: 99% HPLC
Appearance:  White Powder
Typical use:  Hormone replacement therapy
Standard Packing : 10g,100gram,1kg
Shelf Life: 2 years
Storage: Room temperature away from light

Test Items	Test Standards	Test Results
Description	White or off-white crystalline powder	White crystalline powder
Identification	Positive	Positive
Loss on drying	≤0.5%	0.15%
Residue on ignition	≤0.5%	0.05%
Heavy metals	≤20ppm	5ppm
Organic volatile impurities	Accord with USP41 requirement	Complies
Total impurities	≤1.5%	<1.5%
Purity	97.0%~103.0%	99.45%
Conclusion: This batch of product complies with the standard of USP41.

 

Product Name	Finasteride
CAS	98319-26-7
Molecular Formula	C23H36N2O2
Packing Size	100gram,1kg ,25kg or at customers reqirement.

 

 

 

Finasteride can be used for the treatment of hair loss in men. Finasteride belongs to a class of drugs known as 5-alpha-reductase inhibitors. It works by preventing testo from breaking down into DH-T, the hormone that is thought to cause male pattern baldness.

Additionally, it is registered in many countries for androgenetic alopecia (male-pattern baldness).

 

Product Parameters

 

Product Specifications

Items	Standard		Results
Description	White powder		White powder
PH	3.0~4.0		3.1
Water content	≤0.5%		0.1%
Purity	≥99.5%		99.9%
Bulk density	Provide data		0.56g/ml
Residual solvents	Ethanol	<0.05%	0.04%
Contaminant	Pb	≤0.1mg/kg	Complies
	As	≤0.1mg/kg	Complies
	Hg	≤0.1mg/kg	Complies
	Cd	≤0.1mg/kg	Complies
Microbial	Total number of colonies	≤500cfu/g	Complies
	Coliform	≤3MPN/g	Complies
	Mold and yeast	≤25cfu/g	Complies
	Salmonella	Not detected	Complies
	Staphylococcus aureus	Not detected	Complies
	Escherichia coli	Not detected	Complies
Conclusion		The test product complies with the requirements of QS-PP-009(01)

Dutasteride is a basic drug for the treatment of benign prostatic hyperplasia and prostatitis, as well as a drug for male pattern baldness.
1.Treatment of male hair loss.
2.Inhibit the synthesis of DHT, thereby reducing the content of DHT in hair follicles and serum, allowing hair to grow back.

Minoxidil

Product Name	Minoxidil
Brand Name	BIOTECH
1. Categories	Cosmetic Raw Material(Haircare Series)
2. English Name	Minoxidil
3. CAS NO.	38304-91-5
4. Colour	White
5. Purity	99%
6. Original Place	China

(A)Minoxidil Powder can stimulate the proliferation and differentiation of hair follicle epithelial cells: the normal human hair follicle epithelial cells in different concentrations of minoxidil solution in the micro-molar concentration of minoxidil can stimulate hair follicle epithelial cell proliferation.
(B)Minoxidil Powder can promote angiogenesis: increase the local blood supply: hair growth depends on the hair nipple blood supply network nutrition, hair in the different growth cycle, vascular endothelial growth mRNA expression is different from the growth of vascular endothelial growth mRNA in the dermis Nipple cells were strongly expressed, but were less expressed during retrograde and resting periods.
(C)Minoxidil Powde can open potassium channels: potassium channel opening is an important step in regulating hair growth, animal models in vitro and in vivo experiments have shown that minoxidil is a potassium channel activator, can increase the permeability of potassium ions to prevent calcium ion flow Intracellular, resulting in decreased free calcium concentration in cells, while calcium ions, epidermal growth inhibit hair growth.


What is Minoxidil ?
Minoxidil was the first drug approved by the FDA for the treatment of androgenetic alopecia (hair loss). Before that, minoxidil had been used as vasodilator drug prescribed as oral tablet to treat high blood pressure, with side effects that included hair growth and reversal of male baldness. In the 1980s, UpJohn Corporation came out with a topical solution of 2% minoxidil, called Rogaine, for the specific treatment of androgenetic alopecia. Since the 1990s, numerous generic forms of minoxidil have become available to treat hair loss while the oral form is still used to treat high blood pressure.

Minoxidil is a vasodilator medication known for its ability to slow or stop hair loss and promote hair regrowth. It is available over the counter for treatment of androgenic alopecia, among other baldness treatments, but measurable changes disappear within months after discontinuation of treatment. Its effectiveness has largely been demonstrated in younger men (18 to 41 years of age), the younger the better, and in those with balding in the central (vertex) portion of the scalp.

Product Name:    Finasteride
Synonyms:    (5alpha,17beta)-(1,1-dimethylethyl)-3-oxo-4-azaandrost-1-ene-17-carboxamide;17beta-(n-tert-butylcarbamoyl)-4-aza-5alpha-androst-1-en-3-one;4-azaandrost-1-ene-17-carboxamide,n-(1,1-dimethylethyl)-3-oxo-,(5-alpha,17-be;4-azaandrost-1-ene-17-carboxamide,n-(1,1-dimethylethyl)-3-oxo-,(5alpha,17beta;l-652,931;mk-0906;n-tert-butyl-3-oxo-4-aza-5alpha-androst-1-ene-17beta-carboxamide;(5alpha,17beta)-N-(1,1-Dimethylethyl)-3-oxo-4-azaandrost-1-ene-17-carboxamide
CAS:    98319-26-7
MF:    C23H36N2O2
MW:    372.54
EINECS:    620-534-3
Product Categories:    Hormone Drugs;Biochemistry;Steroids;Steroids (Others);Intermediates & Fine Chemicals;Vitamin Ingredients;Active Pharmaceutical Ingredients;API;Pharmaceuticals;Intracellular receptor;Steroid and Hormone;PROSCAR
Mol File:    98319-26-7.mol


Finasteride is a basic drug for the treatment of prostatic hyperplasia and prostatitis in China. It is a synthetic 4-azosterone compound, which is an anti-sex hormone drug that can selectively inhibit 5α-reductase, so that the process of converting testoster one into 5α-dihydrotestoster one (DHT) becomes blocked, the prostate cells in The actual androgen level decreases, the prostate-specific antigen in the serum decreases, the size of the enlarged prostate shrinks, and the urinary flow rate increases, thus reducing the patient's symptoms and achieving the purpose of treating prostate enlargement. The action of the drug is characterized by its ability to selectively block the stimulating effect of androgens on the prostate, yet it rarely affects the sexual function of men. Prostate enlargement, also known as prostate hypertrophy, causes compression of the bladder neck and posterior urethra, causing urinary obstruction and other symptoms and complications that are deeply painful for patients, mostly in the male population over 50 years of age.

Finasteride CAS 98319-26-7 of Chemical Properties
Melting point     253 °C
alpha     405 -59° (c = 1 in methan ol)
Boiling point     576.6±50.0 °C(Predicted)
density     1.065±0.06 g/cm3(Predicted)
storage temp.     room temp
solubility     DMSO: 32 mg/mL, soluble
pka    14.17±0.70(Predicted)
form     solid
color     white to beige
Water Solubility     insoluble
Merck     14,4082
 

Function and Application of Finasteride CAS 98319-26-7
1. Finasteride is a 5α-reductase inhibitor that inhibits the conversion of testoster one to dihydrotestoster one. Used in the treatment of benign prostatic hyperplasia.
2. Finasteride for the treatment of men with enlarged prostate and baldness
 

Product Name:RU58841
CAS:154992-24-2
M.F.:C17H18F3N3O3
Grade:Pharmaceutical Grade
Color:White powder
Purity:99%
Shelf Life:2 years

RU58841 (also known as RU-58841, PSK-3841 or HMR-3841) is a compound that has been garnering attention for its phenomenal response to hair growth. Anti-androgens have potential to be used to treat some 'male' cancers such as prostate cancer, as well as possibly targeting skin conditions including acne and male-pattern baldness. RU58841 differs from other anti-androgens in that rather than trying to reduce or block the production of or DHT, it focuses on the receptor.
RU58841 is a specific androgen receptor antagonist or a so called anti-androgen. This non steroidal topical androgen antagonist was investigated for therapeutic value in androgenetic alopecia and acne. 

Function

1. Strongly compete against DHT.
2. Increase cellular replication rate in the matrix cells.
3. Increase cellular proliferation of outer root sheeth cells.
4. Increase hair diameter and hair density.
5. Increase the percentage of hair in the anagen phase.
6. Exert no negative effect on body hormone levels.
7. Provide equivalent or better net growth than Finasteride.
Application 
1.Treat of glaucoma
Bimatoprost is used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension.It reduces intraocular pressure (IOP) by increasing the outflow of aqueous fluid from the eyes.
2. For growth of lashes as cosmetic
It has also been used and prescribed off-label to lengthen eyelashes
3. For growth of hair
As the FASEB Journal reporting, most of our client bought for the research of hair regrow. they estimate that this will be the next big use for bimatoprost around the world.

RU58841 is an experimental nonsteroidal androgen antagonist (anti-androgen), also known as "topical anti-androgen". Here is a brief introduction to the RU58841 and its possible features:
RU58841 was originally developed as a drug candidate to treat androgenic alopecia. Its mechanism is by inhibiting the binding of androgens to their receptors, thereby blocking the effects of androgens on hair follicles.
While research on RU58841 is still in its early stages, it has been reported to have the following possible properties and efficacy:
Inhibiting the effects of androgens on hair follicles: RU58841 can produce a local anti-androgenic effect on hair follicles by blocking the binding of androgen receptors, thereby reducing the negative effects of androgens on hair and helping to protect and promote hair growth.
Topical Application: RU58841 is typically used as a topical application, directly to the scalp. This topical application reduces the risk of systemic side effects and makes it easier to use.
 

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