| Type: | Pharmaceutical Intermediates, Pharmaceutical Intermediates |
|---|---|
| Appearance: | Powder, Powder |
| Quality: | Technical, Industrial |
| Colour: | White, White |
| CAS No.: | Amitrazrapamycin Sirolimus Powder |
| Formula: | Rapamycin Sirolimus Powder |
| Samples: |
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| Customization: |
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Basic information on Rapamycin Sirolimus Powder:
| Product name | Rapamycin Sirolimus rapamicina em po Polvo |
| CAS No. | 53123-88-9 |
| Molecular formula | C51H79NO13 |
| Molecular weight | 914.17 |
| EINECS number | 610-965-5 |
| Purity | >99% Pure |
Rapamycin has multiple functions and can affect various biological processes in the body. Here are some of the key functions of rapamycin:
1.Immunosuppression: Rapamycin is primarily used as an immunosuppressant drug to prevent organ transplant rejection and treat certain autoimmune diseases. It suppresses the immune system by inhibiting the activation and proliferation of T-lymphocytes, a type of white blood cell involved in immune responses.
2.Inhibition of mTOR signaling: Rapamycin specifically targets a protein called mammalian target of rapamycin (mTOR) and inhibits its activity. mTOR is a central regulator of cell growth, division, and metabolism. By inhibiting mTOR, rapamycin can interfere with cell signaling pathways involved in these processes.
3.Anti-cancer effects: Rapamycin has demonstrated anti-cancer properties by inhibiting tumor growth and metastasis. By blocking mTOR signaling, it disrupts the cellular mechanisms that promote cancer cell proliferation, survival, and angiogenesis. Rapamycin and its analogs (such as everolimus and temsirolimus) have been approved for the treatment of certain cancers, including renal cell carcinoma and certain types of advanced breast cancer.
4. Anti-inflammatory properties: Rapamycin has shown anti-inflammatory effects in various disease models. It can reduce inflammation by modulating immune responses and inhibiting the production of pro-inflammatory molecules.
5.Modulation of autophagy: Autophagy is a cellular process involved in the degradation and recycling of damaged or unnecessary cellular components. Rapamycin can induce autophagy by inhibiting mTOR, leading to the enhanced removal of dysfunctional cellular components and potentially promoting cellular health and longevity.
6.Anti-fibrotic effects: Rapamycin has been investigated for its potential to inhibit the development of fibrosis, a condition characterized by excessive scarring and tissue remodeling. It can interfere with the signaling pathways involved in fibrotic processes and reduce the deposition of extracellular matrix proteins.
Rapamycin is a triene macrolide antibiotic, which demonstrates anti-fungal, anti-inflammatory, anti-tumor and immunosuppressive properties. Rapamycin has been shown to block T-cell activation and proliferation, as well as, the activation of p70 S6 kinase and exhibits strong binding to FK-506 binding proteins.
Rapamycin also inhibits the activity of the protein, mTOR, (mammalian target of rapamycin) which functions in a signaling pathway to promote tumor growth. Rapamycin binds to a receptor protein (FKBP12) and the rapamycin/FKB12 complex then binds to mTOR and prevents interaction of mTOR with target proteins in this signaling pathway..
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