Factory Price 99%+ Purity Dexmedetomidine Dexmedetomidina Dexmedetomidin HCl Powder Hydrochloride Dexmedetomidine CAS 145108-58-3

• Type: Pharmaceutical Intermediates
• Appearance: Powder
• Quality: Technical
• Colour: White
• Certificate: ISO SGS
• Purity: 99%
• Model NO.: Dexmedetomidine
• Transport Package: 25kg/Bag or as Buyer Need
• Specification: 99%
• Trademark: mates
• Origin: China
• HS Code: 2915291000
• Production Capacity: 5000mt/Month

Product Description

 

 

Product Name:    Dexmedetomidine hydrochloride
Synonyms:    4-[(1r)-1-(2,3-dimethylphenyl)ethyl]-3h-imidazole hydrochloride;4-((s)-alpha,2,3-trimethylbenzyl)imidazole monohydrochloride;DEXMEDETOMIDINE HCL;DEXMEDETOMIDINE HYDROCHLORIDE;DEMEDETOMIDINE HCL;Dexmedetomidine(Pilot);4-[(1S)-1-(2,3-Dimethylphenyl)ethyl]-1H-imidazolehydrochloride;4-((S)-α,2,3-Trimethylbenzyl)imidazole monohydrochloride
CAS:    145108-58-3
MF:    C13H17ClN2
MW:    236.74
EINECS:    682-047-2
Product Categories:    Inhibitors;API;145108-58-3
Mol File:    145108-58-3.mol


Dexmedetomidine was launched in the US as an i.v. infusion for sedation of initially intubated and mechanically ventilated patients during treatment in an intensive care unit, This imidazole derivative is the (S)-enantiomer of medetomidine that can be obtained via fractional crystallization of the tartrate salt of the racemic mixture. Dexmedetomidine is a full agonist of α2 adrenoceptors with 1300-fold selectivity versus α1 compared to the less selective partial α2 agonist clonidine, a veterinary hypnotic. Dexmedetomidine is unique compared with currently available sedatives in that it provides sedation, analgesia and anxiolysis with the ability of patients to be easily awakened. Besides, it causes minimal respiratory depression unlike other available drugs such as benzodiazepin e s or opioids. Pharmacological studies in transgenic mice showed that the sedative, anesthetic and analgesic effects of dexmedetomidine are specifically due to the stimulation of the a2A subtype receptor. Like other α2 adrenoceptor agonists, dexmedetomidine can provoke hypotension and bradycardia probably because of its non-selective action on peripheral a2B subtype receptors in vascular smooth muscle. Dexmedetomidine is extensively metabolized into methyl and glucuronide conjugates which are mainly eliminated by renal excretion. It was found to be a CYP2D6 inhibitor but less potent than the clinically relevant standard quinidine.


Dexmedetomidine Hcl CAS 145108-58-3 of Chemical Properties
Melting point     156.5-157.5°
alpha     +52.4° (c = 1 in water)
density     1.17 g/cm3
storage temp.     2-8°C
solubility     H2O: soluble20mg/mL, clear
form     powder
color     white to beige
optical activity    [α]/D +48 to +58°, c = 1 in H2O
Merck     14,2946
InChIKey    VPNGEIHDPSLNMU-MERQFXBCSA-N
CAS DataBase Reference    145108-58-3(CAS DataBase Reference)

Function and Application of Dexmedetomidine Hcl CAS 145108-58-3

1. Dexmedetomidine hydrochloride has been used to study its effects on primary neonatal rat cardiomyocytes under hypoxic/reoxygenation conditions. It has also been used to study the effects of dexmedetomidine pretreatment on lipopolysaccharide-induced acute lung injury in mice.
2. highly selective, potent α2-adrenoceptor agonist, analgesic, anxiolytic, bradycardic, hypotensive, sedative, hypothermic

Packing And Shipping
1.Preferentially DHL, FedEX or TNT for quantity less than 50kg, air shipping for 100kg above, sea shipping for quantity over 500kg.
2.For customers from Russia,Mexico,Turkey,Solvenia,Romania,etc,before placing an order,please kindly confirm if you can make clearance when goods reach your customs.

Shipping Terms
By Express	By Air	By Sea
Suitable for under 50kg Fast:3-4 days High cost Door to door service Easy to pick up the goods	Suitable for more than 50kg Fast:3-4 days High cost Airport to airport Professional broker needed	Suitable for more than 500kg Slow:15-30 days Low cost Port to port Professional broker needed

 

Packaging & Shipping









FAQ

 

Q1: Can I get samples?
A: Yes, we can supply free sample, you pay for the freight charge only.

Q2: How to pay? 
A: PI will be sent firstly after our aligned products specification. Payment by Paypal , T/T, Western Union,LC, are ok.

Q3: How is your MOQ? 
A: Normally speaking, our MOQ is 1kg. But we can also accept less quantity such as 100g on the condition that sample charge is100% paid.

Q4: How can you guarantee the quality of your products ?
1. Our staff are all experienced in chemical products or related major background, they are well trained before quotation.
2. Free sample or pre-shipment sample are available for our new cooperation before you place commercial order. We are sure the same specification commercial products as sample to customers
3. Third Party Inspection like SGS can be arranged according to your requirement before shipping.
4. On-Spot QC in our APPROVED associated production bases with necessary certification like GMP, ISO etc.